实验研究部

2017/08-至今，中山大学，附属第五医院，副研究员

2016/07-2017/07，新加坡国立大学，资深博士后

2012/02-2016/06，新加坡国立大学，博士后

2006/01-2011/11，南洋理工大学（新加坡），博士

1. 海洋天然产物药理、 类器官与药物筛选     

2. 基于AI的病理-药理-组学分析与靶点发现

3. 微生物菌群与肿瘤   

4. Hippo信号通路

在研科研项目：

代表性文章

论文(#, co-first author, *, co-corresponding author)

1、Yuyang Sha^#, Li Yu^#, Zehui Lin, Amandeep Kaur, Yanyan Lou, Shivanand S Gornale, Tianyu Zhang, Ling Shing Wong, Zhiwen Wang, Yan Yan, Xianbin Zhang, Rui Hong, Ka Li, Sio Kei Im, Paulo de Carvalho*, Tao Tan* and Ke-Feng Li*. A roadmap for medical large language models: a review of foundations, applications, and challenges. Military Medical Research 2026 (in press, review)

2、Yichen Luo^#, Yanhong Han^#, Huilong Nie^#, Minghao Feng^#, Cuiting Wei, Xiuling Ma, Kefeng Li, Zhuangzhuang Zhang, Guangxue Wang, Wenjun Pan, Xueyang Li, Liutong Yi, De-Yun Wang, Xiantao Zeng, Yongkang Qiao*, Yan Yan*, Yujing Lin*. Tyrosine Hydroxylase as a Therapeutic Target: Insights from Adrenergic Nerve and TNBC Cell Interactions. Journal of Molecular Medicine 2026, 104:53

3、Zixuan Liu, Yuanyuan Shi, Disheng Zhou, Shuna Chen, Xueqi Liu, Yuting Huang, Ziyi Yang, Yanting Liang, Mini Huang, Yan Yan, Yongkang Qiao, Ying Ma, Liu Huan, Lin Qi, Miao Li*, Sze-Hoi Chen*, Xing-Ding Zhang*. Role of MED15 in Enhancing EMT and Metastasis in Bladder Cancer through YAP1 Stabilization. FASEB J 2026 Feb 28;40(4):e71558.

4、Junjun Ji, Zhifan Li, Abao Xing, Gang Luo, Xiaobing Zhai, Wei Xu, Junrong Li, Tao Tan, Ruihong Jia, Yan Yan, Xianbin Zhang, Long Wang, Junfeng Li, Kefeng Li*. Causal Relationships Between Alzheimer's Disease Genetics and Brain Connectivity Alterations: A Multi-modal Mendelian Randomization Study with Transcriptomic Validation of 191 rs-fMRI and 635 DTI Neuroimaging Traits. Brain Imaging and Behavior2026, 20:57

5、Shuya Ren^#, Yanhong Han^#, Yan Yan, Yuran Zhou, Siwen Yuan, Junjie Chen, Heng Guo, Zhenjian Lin, Qifeng Lin, Senhua Chen, Lan Liu, Yongkang Qiao*, Zhizeng Gao*. Two Novel Peniphenone Derivatives with Distinct Stereoconfigurations from Ascidian-Derived Fungus Diaporthe sp. SYSU-MS4722 and Their Anti-Fibrotic Activities. Journal of Ocean University of China 2026, (25)3:1-7

6、Xiuting Huang^#, Yuan Zhuang^#, Rui Wang^#, Jing Qu^#, Yuanyang Tan^#, Liang Li, Wenjun Pan, Huilong Nie, Kefeng Li, Yujing Lin, Liutong Yi, Xiaoyu Feng, Huiming Lan, Guangxue Wang, Xiantao Zeng, Zhenqi Jiang, De-Yun Wang*, Yongkang Qiao*, Yan Yan*. Colonization by Porphyromonas gingivalis in Cervical Squamous Cell Carcinomas Promotes Metastasis through FimA/CD151/ITGB1 Signaling. Journal of Translational Medicine 2025，23:1166.

7、Yichen Luo, Xiuting Huang, Rui Wang, Yujing Lin, Jiaxin Sun, Kefeng Li, De-Yun Wang, Yan Yan, Yongkang Qiao*. Advancements in understanding tumor-resident bacteria and their application in cancer therapy. Military Medical Research 2025 Jul 25;12(1):38.（review）

8、Yanrong Guo^#, Yuran Zhou^#, Rui Wang, Yujing Lin, Huimin Lan, Yang Li, De-Yun Wang, Jinrui Dong, Kefeng Li, Yan Yan*, Yongkang Qiao*. YAP as a potential therapeutic target for myofibroblast formation in asthma. Respiratory Research 2025, 26(1):51.

9、Shuya Ren^#, Yan Yan^#, Yuran Zhou^#, Yanhong Han, Siwen Yuan, Junjie Chen, Heng Guo, Zhenjian Lin, Qifeng Lin, Senhua Chen, Lan Liu, Yongkang Qiao*, Zhizeng Gao*. Genome Mining of Nonenzymatic ortho-Quinone Methide Based Pseudonatural Products from Ascidian-Derived Fungus Diaporthe sp.SYSU-MS4722. Bioorganic Chemistry 2025,154:108081.

10、Siwen Yuan^#, Shitao Zhuang^#, Yanhong Han, Yuhang Wen, Senhua Chen, Lan Liu, Qifeng Lin, Yan Yan*, Zhizeng Gao*, Qilin Wu*. Genome Mining of Monoterpenes from Ascidian-Derived fungus Diaporthe sp. SYSU-MS4722. Frontiers in Microbiology 2025, 16:1593027.

11、Siwen Yuan^#, Shitao Zhuang^#, Yongkang Qiao^#, Qilin Wu, Yutong Ma, Senhua Chen, Lan Liu, Yan Yan*, Zhizeng Gao*. Metabolic Shunting in Marine-Derived Diaporthe sp. SYSU-MS4722 Yields Diverse γ-Butyrolactone Derivatives with Anti-Inflammatory Activity. Journal of Natural Products 2025 Jul 25;88(7):1605-1615

12、Meiting Ma, Zhengqi Chu, Hongyu Quan, Hanxu Li, Yuran Zhou, Yanhong Han, Kefeng Li, Wenjun Pan, De-Yun Wang, Yan Yan, Zunpeng Shu, Yongkang Qiao*. Natural products for anti-fibrotic therapy in idiopathic pulmonary fibrosis: marine and terrestrial insights. Frontiers in Pharmacology2025, 16:1524654. (review)

13、Yuyang Sha^#, Meiting Jiang^#, Gang Luo^#, Weiyu Meng, Xiaobing Zhai, Hongxin Pan, Junrong Li, Yan Yan, Yongkang Qiao*, Wenzhi Yang*, Kefeng Li*. HerbMet: A Framework for Chinese Herbal Medicine Identification via Deep Learning and Metabolomics Data. Phytochemical Analysis 2025 Jan;36(1):261-272.

14、Yuanyang Tan^#, Huiqin Zhou^#, Yujing Lin^#, Liutong Yi^#, Zhuanggui Chen, Qingdong Cao, Yanrong Guo, Zhaoni Wang, Shoudeng Chen, Yang Li, De-Yun Wang, Yong-Kang Qiao*, Yan Yan*. FGF2 is overexpressed in asthma and promotes airway inflammation through FGFR/MAPK/NF-κB pathway in airway epithelial cells. Military Medical Research, 2022, 9:7

15、Guihua Zhong^#, Wei Wei^#, Wei Liao^#, Rong Wang, Yingpeng Peng, Yuling Zhou, Xiaotao Huang, Shiping Xian, Shunli Peng, Zhaoyuan Zhang, Shaoyan Feng, Ye Liu, Haiyu Hong, Yunfei Xia, Yan Yan*, Qiaodan Liu*, Zhigang Liu*. Tumor microbiome in nasopharyngeal carcinoma and its association with prognosis. Frontiers in Oncology, 2022 May 23;12:859721.

16、Haiyu Hong^#, Kai Sen Tan^#, Yan Yan^#, Fenghong Chen^#, Hsiao Hui Ong, Yukei Oo, Jing Liu, Yew Kwong Ong, Mark Thong, Richard Sugrue, Vincent T Chow*, De-Yun Wang*. Induction of IL-25 Expression in Human Nasal Polyp Epithelium by Influenza Virus Infection is Abated by Interferon-Alpha Pretreatment. Journal of Inflammation Research, 2021,14:2769-2780

17、Yuanyang Tan^#, Yongkang Qiao^#, Zhuanggui Chen, Jing Liu, Yanrong Guo, Thai Tran, Kai Sen Tan, De-Yun Wang*, Yan Yan*. FGF2, an immunomodulatory factor in asthma and chronic obstructive pulmonary disease (COPD). Frontiers in Cell and Developmental Biology, 2020,8:223.(review)

18、Zhaoni Wang^#, Ruonan Su^#, Biyun Yang, Kexin Yang, Lifen Yang, Yan Yan*, Zhuanggui Chen*.Potential role of cellular senescence in asthma. Frontiers in Cell and Developmental Biology, 2020,8:59. (review)

19、Yanrong Guo^#, Qingdong Cao^#, Zhongsi Hong^#, Yuanyang Tan, Shoudeng Chen, Hongjun Jin, Kai Sen Tan, De-Yun Wang*, Yan Yan*. The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak - an update on the status. Military Medial Research, 2020,7(1):11. (review)

20、Sisi Kang, Mei Yang, Zhongsi Hong, Liping Zhang, Zhaoxia Huang, Xiaoxue Chen, Suhua He, Ziliang Zhou, Zhechong Zhou, Qiuyue Chen, Yan Yan, Changsheng Zhang, Hong Shan*, Shoudeng Chen*. Crystal structure of SARS-CoV-2 nucleocapsid protein RNA binding domain reveals potental unique drug targeting sites. Acta Pharm Sin B, 2020. 10(7):1228-1238

21、Kai Sen Tan^#, Anand Kumar Andiappan^#, Bernett Lee^#, Yan Yan^#, Jing liu^#, See Aik Tang, Josephine Lum, Yew Kwang Ong, Kim Thye Thong, Hui Fang Lim, Hyung Won Choi, Olaf Rotzschke, Vincent T Chow*, De Yun Wang*. RNA sequencing of H3N2 influenza virus-infected human nasal epithelial cells from multiple subjects reveals molecular pathways associated with tissue injury and complications. Cells2019. 8(9). pii: E986.

22、Qintai Yang^#, Chunwei Li^#, Weihao Wang^#, Rui Zheng, Xuekun Huang, Huiyi Deng, Peng Jin, Kai Sen Tan, Yan Yan, De Yun Wang*. Infiltration pattern of gammadelta T cells and its association with local inflammatory response in the nasal mucosa of patients with allergic rhinitis. International Forum of Allergy and Rhinology 2019, 9(11):1318-1326.

23、Zhuanggui Chen^#, Zhaoni Wang^#, Yan Yan, Jing Liu, Ting Ting He, Kim Thye Thong, Yew Kwang Ong, Vincent T. K. Chow, Kai Sen Tan*, De Yun Wang. Upregulation of cell-surface MUC15 in human nasal epithelial cells upon influenza A virus infection. BMC Infectious Diseases 2019, 19:622 

24、Yongkang Qiao^#, Yan Yan^#, Kai Sen Tan^#, Sheryl SL Tan^#, Ju Ee Seet, Thiruma Valavan Arumugam, Vincent T Chow, De-Yun Wang *, Thai Tran*. CD151, a novel host factor of nuclear export signaling in influenza virus infection. Journal of Allergy and Clinical Immunology 2018, 141(5), 1799-1817.

25、Kai Sen Tan^#, Yan Yan^#, Wai Ling Hiromi Koh^#, Liang Li, Hyungwon Choi, Thai Tran, Richard Sugrue, De Yun Wang*, Vincent T Chow*. Comparative transcriptomic and metagenomic analyses of influenza virus-infected nasal epithelial cells from multiple individuals reveal specific nasal-initiated signatures. Frontiers in Microbiology2018, 9:2685

26、Huong Tra^#, Yan Yan^#, Muhammad Jumat, Jing Liu, Boon Huan Tan, De Yun Wang, Richard Sugrue*. A sustained antiviral host response in respiratory syncytial virus infected human nasal epithelium does not prevent virus transmission. Virology 2018, 521, 22-32.

27、Kai Sen Tan^#, Hsiao Hui Ong^#, Yan Yan^#, Jing Liu^#, Yew Kwang Ong, Kim Thye Thong, Hyung Wong Choi, De-Yun Wang*,Vincent T Chow*. In vitro model of fully differentiated human nasal epithelial cells infected with rhinovirus reveals epithelium-initiated immune responses. Journal of Infectious Diseases 2018, 217:906-915.

28、Annika Luukkainen^#, Kia Puan^#, Nurhashikin Yusof, Bernett Lee, Kai Sen Tan, Jing Liu, Yan Yan, Sanna Salmi, Risto Renkonen, Vincent T Chow, Olaf Rotzschke, De Yun Wang*. A co-culture model of PBMC and stem cell derived human nasal epithelium reveals rapid activation of NK and innate T cells upon Influenza A virus infection of the nasal epithelium. Frontiers in Immunology 2018, 9:2514.

29、Tengfei Tian, Xiaoxue Zi, Yang Peng, Zhaoni Wang, Haiyu Hong, Yan Yan, Weijie Guan, Kai Sen Tan, Jing Liu, Hsiao Hui Ong, Xue Kang, Jieqing Yu, Yew Kwang Ong, Kim Thye Thong, Li Shi, Jing Ye, De-Yun Wang*. H3N2 influenza virus infection enhances Oncostatin M expression in human nasal epithelium. Experimental Cell Research 2018, 371:322-329.

30、Yunfei Gao^#, Jiaopin Mi^#, Fenghong Chen, Zhenpeng Liao, Shaoyan Feng, Minghui Lv, Haixin He, Yujie Cao, Yan Yan, Zhe Zhu, Yunping Fan*, Haiyu Hong*. Detection of GSK-3β activation index in pediatric chronic tonsillitis is an indicator for chronic recurrent inflammation. American Journal of Otolaryngology 2018;39(3):277-281.

31、Peng Jin, Xiaoxue Zi, Tze Chong Charn, Jing Liu, Yan Yan, Li Shi, Hailing Zhang*, De Yun Wang*. Histopathological Features of Antrochoanal Polyps in Chinese Patients. Rhinology 2018, 56(4):378-385.

32、Jing Liu^#, Yingying Li^#, Andiappan Anand, Yan Yan, Kai Sen Tan, Hsiao Hui Ong, Mark KT Thong, Yew Kwang Ong, Fenggang Yu, Heng Boon Low, Yongliang Zhang, Li Shi *, De Yun Wang*. Role of IL-13Ra2 in modulating IL-13 induced MUC5AC and ciliary changes in healthy and CRSwNP mucosa. Allergy 2018,73(8):1673-1685. 

33、Zhuo Chen^#, Yang Peng^#, Chew Lip Ng, Peng Jin, Jing Liu, Yingying Li, Yan Yan, Yanhui Liu, Xinlan Luo, Qianhui Qiu*, De-Yun Wang. The clinical characteristics and histopathological features of chronic rhinosinusitis with unilateral nasal polyps in 136 patients in Southern China. Clinical Otolaryngololgy 2018, 43(5):1345-1349. 

34、Qianhui Qiu^#, Yang Peng^#, Zhenchao Zhu, Zhuo Chen, Chi Zhang, Hsiao Hui Ong, Kai Sen Tan, Haiyu Hong, Yan Yan, Haoqi Huang, Jing Liu, Xianqing Li, HN Nam, NTN Dung, Li Shi, Qintai Yang, Colin D Bingle, De Yun Wang*. Absence or mislocalization of DNAH5 is a characteristic marker for motile ciliary abnormality in nasal polyps. Laryngoscope 2018, 128(3):E97-E104.

35、Zhuanggui Chen^#, Pin Meng^#, Hongtao Li, Ming Li, Lifan Yang, Yan Yan, Yating Li, Xiaoling Zou, De-Yun Wang*, Tian-Tuo Zhang*. Thymic stromal lymphopoietin contribution to the recruitment of circulating fibrocytes to the lung in a mouse model of chronic allergic asthma. Journal of Asthma 2018, 55(9):975-983. 

36、Kai Sen Tan^#, Yan Yan^#, Hsiao Hui Ong, Vincent T Chow, Li Shi, De-Yun Wang*. Impact of respiratory virus infections in exacerbation of acute and chronic rhinosinusitis. Current Allergy and Asthma Reports 2017,17(4):24.

37、Yuqin Deng^#, Yan Yan^#, Kai Sen Tan^#, Jing Liu, Vincent T Chow, Ze-Zhang Tao*, De-Yun Wang*. MicroRNA-146a induction during influenza H3N2 virus infection targets and regulates TRAF6 levels in human nasal epithelial cells (hNECs). Experimental Cell Research 2017,15;352(2):184-192.

38、Haiyu Hong^#, Fenghong Chen^#, Yongkang Qiao^#, Yan Yan, Rongkai Zhang, Zhe Zhu, Huabin Li, Yunping Fan*, Geng Xu*. GSK-3β activation index is a potential indicator for recurrent inflammation of chronic rhinosinusitis without nasal polyps. Journal of Cellular and Molecular Medicine 2017, 21 (12), 3633-3640. 

39、Yan Yan^#, Kai Sen Tan^#, Chunwei Li, Thai Tran, Siew Shuen Chao, Richard J Sugrue, Li Shi, Vincent T Chow *, De-Yun Wang *. Human nasal epithelial cells derived from multiple individuals exhibit differential responses to H3N2 influenza virus infection in vitro. Journal of Allergy and Clinical Immunology 2016,138(1):276-281.

代表性专利

1、发明专利，一种聚酮化合物及其在制备抗肺纤维化的药物中的应用， ZL20241023000.5，发明人：骆奕辰，周昱然，王锐，严彦，高志增，任淑雅

2、实用新型专利，自然腔道上皮组织细胞收集装置， ZL202323058373.8，发明人：骆奕辰，林宇静，严彦，兰慧敏

3、发明专利，一种聚酮类二聚体化合物及其在制备抗肺纤维化的药物中的应用，申请号2024102351913（实审中）发明人：严彦，骆奕辰，周昱然，高志增，任淑雅

4、发明专利，一种肿瘤-神经细胞互作模型，申请号2024108472841（实审中），发明人：骆奕辰，严彦，魏崔婷，刘彦君，姚逸凡，庄诗涛，王哲彦

2023年：Military Medical Research期刊2020-2023年度杰出贡献（高被引论文）奖

2021年：珠海市高层次人才（三类）

2021年：中大五院2020-2021年度优秀科技工作者

2019年：广东省杰出青年医学人才

2017年：中山大学“百人计划二期”引进人才