实验研究部

2017/08-至今，中山大学，附属第五医院，副研究员

2016/07-2017/07，新加坡国立大学，资深博士后

2012/02-2016/06，新加坡国立大学，博士后

2006/01-2011/11，南洋理工大学（新加坡），博士

1. 海洋天然产物药理、 类器官与药物筛选     

2. 基于AI的病理-药理-组学分析与靶点发现

3. 微生物菌群与肿瘤   

4. Hippo信号通路

在研科研项目：

近期代表性文章

1. Yichen Luo^#, Yanhong Han^#, Huilong Nie^#, Minghao Feng^#, Cuiting Wei, Xiuling Ma, Kefeng Li, Zhuangzhuang Zhang, Guangxue Wang, Wenjun Pan, Xueyang Li, Liutong Yi, De-Yun Wang, Xiantao Zeng, Yongkang Qiao*, Yan Yan*, Yujing Lin*. Tyrosine Hydroxylase as a Therapeutic Target: Insights from Adrenergic Nerve and TNBC Cell Interactions. Journal of Molecular Medicine 2026, 104:53

2. Zixuan Liu, Yuanyuan Shi, Disheng Zhou, Shuna Chen, Xueqi Liu, Yuting Huang, Ziyi Yang, Yanting Liang, Mini Huang, Yan Yan, Yongkang Qiao, Ying Ma, Liu Huan, Lin Qi, Miao Li*, Sze-Hoi Chen*, Xing-Ding Zhang*. Role of MED15 in Enhancing EMT and Metastasis in Bladder Cancer through YAP1 Stabilization. FASEB J 2026 Feb 28;40(4):e71558.

3. Xiuting Huang^#, Yuan Zhuang^#, Rui Wang^#, Jing Qu^#, Yuanyang Tan^#, Liang Li, Wenjun Pan, Huilong Nie, Kefeng Li, Yujing Lin, Liutong Yi, Xiaoyu Feng, Huiming Lan, Guangxue Wang, Xiantao Zeng, Zhenqi Jiang, De-Yun Wang*, Yongkang Qiao*, Yan Yan*. Colonization by Porphyromonas gingivalis in Cervical Squamous Cell Carcinomas Promotes Metastasis through FimA/CD151/ITGB1 Signaling. Journal of Translational Medicine 2025  23:1166.

4. Yichen Luo, Xiuting Huang, Rui Wang, Yujing Lin, Jiaxin Sun, Kefeng Li, De-Yun Wang, Yan Yan, Yongkang Qiao*. Advancements in understanding tumor-resident bacteria and their application in cancer therapy. Military Medical Research 2025 Jul 25;12(1):38.（review）

5. Junjun Ji, Zhifan Li, Abao Xing, Gang Luo, Xiaobing Zhai, Wei Xu, Junrong Li, Tao Tan, Ruihong Jia, Yan Yan, Xianbin Zhang, Long Wang, Junfeng Li, Kefeng Li*. Causal Relationships Between Alzheimer's Disease Genetics and Brain Connectivity Alterations: A Multi-modal Mendelian Randomization Study with Transcriptomic Validation of 191 rs-fMRI and 635 DTI Neuroimaging Traits. Brain Imaging and Behavior 2026 (in press)

6. Shuya Ren^#, Yanhong Han^#, Yan Yan, Yuran Zhou, Siwen Yuan, Junjie Chen, Heng Guo, Zhenjian Lin, Qifeng Lin, Senhua Chen, Lan Liu, Yongkang Qiao*, Zhizeng Gao*. Two Novel Peniphenone Derivatives with Distinct Stereoconfigurations from Ascidian-Derived Fungus Diaporthe sp. SYSU-MS4722 and Their Anti-Fibrotic Activities. Journal of Ocean University of China 2026, (25)3:1-7

7. Shuya Ren^#, Yan Yan^#, Yuran Zhou^#, Yanhong Han, Siwen Yuan, Junjie Chen, Heng Guo, Zhenjian Lin, Qifeng Lin, Senhua Chen, Lan Liu, Yongkang Qiao*, Zhizeng Gao*. Genome Mining of Nonenzymatic ortho-Quinone Methide Based Pseudonatural Products from Ascidian-Derived Fungus Diaporthe sp.SYSU-MS4722. Bioorganic Chemistry 2025,154:108081.

8. Siwen Yuan^#, Shitao Zhuang^#, Yanhong Han, Yuhang Wen, Senhua Chen, Lan Liu, Qifeng Lin, Yan Yan*, Zhizeng Gao*, Qilin Wu*. Genome Mining of Monoterpenes from Ascidian-Derived fungus Diaporthe sp. SYSU-MS4722. Frontiers in Microbiology 2025, 16:1593027.

9. Siwen Yuan^#, Shitao Zhuang^#, Yongkang Qiao^#, Qilin Wu, Yutong Ma, Senhua Chen, Lan Liu, Yan Yan*, Zhizeng Gao*. Metabolic Shunting in Marine-Derived Diaporthe sp. SYSU-MS4722 Yields Diverse γ-Butyrolactone Derivatives with Anti-Inflammatory Activity. Journal of Natural Products 2025 Jul 25;88(7):1605-1615

10. Meiting Ma, Zhengqi Chu, Hongyu Quan, Hanxu Li, Yuran Zhou, Yanhong Han, Kefeng Li, Wenjun Pan, De-Yun Wang, Yan Yan, Zunpeng Shu, Yongkang Qiao*. Natural products for anti-fibrotic therapy in idiopathic pulmonary fibrosis: marine and terrestrial insights. Frontiers in Pharmacology 2025, 16:1524654. (review)

11. Yuyang Sha^#, Meiting Jiang^#, Gang Luo^#, Weiyu Meng, Xiaobing Zhai, Hongxin Pan, Junrong Li, Yan Yan, Yongkang Qiao*, Wenzhi Yang*, Kefeng Li*. HerbMet: A Framework for Chinese Herbal Medicine Identification via Deep Learning and Metabolomics Data. Phytochemical Analysis 2025 Jan;36(1):261-272.

12. Yanrong Guo^#, Yuran Zhou^#, Rui Wang, Yujing Lin, Huimin Lan, Yang Li, De-Yun Wang, Jinrui Dong, Kefeng Li, Yan Yan*, Yongkang Qiao*. YAP as a potential therapeutic target for myofibroblast formation in asthma. Respiratory Research 2025, 26(1):51.

13. Yuanyang Tan^#, Huiqin Zhou^#, Yujing Lin^#, Liutong Yi^#, Zhuanggui Chen, Qingdong Cao, Yanrong Guo, Zhaoni Wang, Shoudeng Chen, Yang Li, De-Yun Wang, Yong-Kang Qiao*, Yan Yan*. FGF2 is overexpressed in asthma and promotes airway inflammation through FGFR/MAPK/NF-κB pathway in airway epithelial cells. Military Medical Research, 2022, 9:7

14. Guihua Zhong^#, Wei Wei^#, Wei Liao^#, Rong Wang, Yingpeng Peng, Yuling Zhou, Xiaotao Huang, Shiping Xian, Shunli Peng, Zhaoyuan Zhang, Shaoyan Feng, Ye Liu, Haiyu Hong, Yunfei Xia, Yan Yan*, Qiaodan Liu*, Zhigang Liu*. Tumor microbiome in nasopharyngeal carcinoma and its association with prognosis. Frontiers in Oncology, 2022 May 23;12:859721.

15. Haiyu Hong^#, Kai Sen Tan^#, Yan Yan^#, Fenghong Chen^#, Hsiao Hui Ong, Yukei Oo, Jing Liu, Yew Kwong Ong, Mark Thong, Richard Sugrue, Vincent T Chow*, De-Yun Wang*. Induction of IL-25 Expression in Human Nasal Polyp Epithelium by Influenza Virus Infection is Abated by Interferon-Alpha Pretreatment. Journal of Inflammation Research, 2021.14:2769-2780

16. Yuanyang Tan^#, Yongkang Qiao^#, Zhuanggui Chen, Jing Liu, Yanrong Guo, Thai Tran, Kai Sen Tan, De-Yun Wang*, Yan Yan*. FGF2, an immunomodulatory factor in asthma and chronic obstructive pulmonary disease (COPD). Frontiers in Cell and Developmental Biology, 2020,8:223.(review)

17. Zhaoni Wang^#, Ruonan Su^#, Biyun Yang, Kexin Yang, Lifen Yang, Yan Yan*, Zhuanggui Chen*.Potential role of cellular senescence in asthma. Frontiers in Cell and Developmental Biology, 2020,8:59. (review)

18. Yanrong Guo^#, Qingdong Cao^#, Zhongsi Hong^#, Yuanyang Tan, Shoudeng Chen, Hongjun Jin, Kai Sen Tan, De-Yun Wang*, Yan Yan*. The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak - an update on the status. Military Medial Research, 2020,7(1):11. (review)

19. Sisi Kang, Mei Yang, Zhongsi Hong, Liping Zhang, Zhaoxia Huang, Xiaoxue Chen, Suhua He, Ziliang Zhou, Zhechong Zhou, Qiuyue Chen, Yan Yan, Changsheng Zhang, Hong Shan*, Shoudeng Chen*. Crystal structure of SARS-CoV-2 nucleocapsid protein RNA binding domain reveals potental unique drug targeting sites. Acta Pharm Sin B, 2020. 10(7):1228-1238

20. Yongkang Qiao^#, Yan Yan^#, Kai Sen Tan^#, Sheryl SL Tan^#, Ju Ee Seet, Thiruma Valavan Arumugam, Vincent T Chow, De-Yun Wang *, Thai Tran*. CD151, a novel host factor of nuclear export signaling in influenza virus infection. Journal of Allergy and Clinical Immunology 2018. 141(5), 1799-1817.

21. Yan Yan^#, Kai Sen Tan^#, Chunwei Li, Thai Tran, Siew Shuen Chao, Richard J Sugrue, Li Shi, Vincent T Chow *, De-Yun Wang *. Human nasal epithelial cells derived from multiple individuals exhibit differential responses to H3N2 influenza virus infection in vitro. Journal of Allergy and Clinical Immunology 2016,138(1):276-281.

近期代表性专利

1.发明专利，一种聚酮化合物及其在制备抗肺纤维化的药物中的应用， ZL20241023000.5，发明人：骆奕辰，周昱然，王锐，严彦，高志增，任淑雅

2.实用新型专利，自然腔道上皮组织细胞收集装置， ZL202323058373.8，发明人：骆奕辰，林宇静，严彦，兰慧敏

3.发明专利，一种聚酮类二聚体化合物及其在制备抗肺纤维化的药物中的应用，申请号2024102351913（实审中），发明人：严彦，骆奕辰，周昱然，高志增，任淑雅

4.发明专利，一种预测三阴性乳腺癌顺铂药物敏感性的标志物及其应用，申请号2024105530296（实审中），发明人：骆奕辰，严彦，林宇静，聂惠龙，魏崔婷，刘彦君，董杰

5.发明专利，一种肿瘤-神经细胞互作模型，申请号2024108472841（实审中），发明人：骆奕辰，严彦，魏崔婷，刘彦君，姚逸凡，庄诗涛，王哲彦

2023年：Military Medical Research期刊2020-2023年度杰出贡献（高被引论文）奖

2021年：珠海市高层次人才（三类）

2021年：中大五院2020-2021年度优秀科技工作者

2019年：广东省杰出青年医学人才

2017年：中山大学“百人计划二期”引进人才