实验研究部

1. 教育经历

2010-2015：广东医科大学 医学检验学院，学士

2015-2018：南方医科大学 第二临床医学院，硕士

2018-2021：中山大学 附属第五医院，博士

2. 科研与工作经历

2021/09-2025/02：中山大学附属第五医院 博士后

2025/03-至今：中山大学附属第五医院，副研究员

1. 免疫细胞在肿瘤治疗中的应用；

 2. 细胞外囊泡在肿瘤和感染性疾病中的应用。

国家自然科学基金青年科学基金项目，82303799，负载STING激动剂的DC靶向性肿瘤细胞囊泡增强CAR-T细胞抗肿瘤能力的研究，2024/01-2026/12，主持

1.Zhu T#, Xiao Y, Chen Z, Chen S*, Jiang G*, Huang X*. Inhalable nanovesicles loaded with a STING agonist enhance CAR-T cell activity against solid tumors in the lung. Nat Commun. 2025 Jan 2;16(1):262. 

2.Zhu T, Chen Z, Jiang G, Huang X*. Sequential Targeting Hybrid Nanovesicles Composed of Chimeric Antigen Receptor T-Cell-Derived Exosomes and Liposomes for Enhanced Cancer Immunochemotherapy. ACS Nano.2023 Sep 12;17(17):16770-16786. 

3.Zhu T#, Xiao Y#, Meng X#, Tang L, Li B, Zhao Z, Tan Q, Shan H*, Liu L*, Huang X*. Nanovesicles derived from bispecific CAR-T cells targeting the spike protein of SARS-CoV-2 for treating COVID-19. J Nanobiotechnology. 2021 Nov 25;19(1):391. 

4.Xiao Y#, Zhu T#, Chen Z, Huang X*. Lung metastasis and recurrence is mitigated by CAR macrophages, in-situ-generated from mRNA delivered by small extracellular vesicles. Nat Commun. 2025 Aug 4;16(1):7166.

5.Wang R#, Li X#, Fu G, Hu M, Dou H, Zhang G, Pengshun Q, Mao J, Zhu T*, Cao Q*. Hybrid nanovesicles comprising induced pluripotent stem cells and dendritic cell-derived exosomes enhance antitumor immunity. Chem Eng J, 2024 Sep 15;496: 154170. 

6.Li X#, Zhu T#, Wang R#, Chen J#, Tang L, Huo W*, Huang X*, Cao Q*. Genetically Programmable Vesicles for Enhancing CAR-T Therapy Against Solid Tumors. Adv Mater. 2023 Feb 22:e2211138. 

7.Chen J#, Zhu T#, Jiang G, Zeng Q, Li Z, Huang X*. Target delivery of a PD-1-TREM2 scFv by CAR-T cells enhances anti-tumor efficacy in colorectal cancer. Mol Cancer. 2023 Aug 10;22(1):131. 

8.Wang R#, Zhu T#, Hou B*, Huang X*. An iPSC-derived exosome-pulsed dendritic cell vaccine boosts antitumor immunity in melanoma. Mol Ther. 2023 Aug 2;31(8):2376-2390. 

9.Xiao Y#, Zhu T#, Zeng Q, Tan Q, Jiang G*, Huang X*. Functionalized biomimetic nanoparticles combining programmed death-1/programmed death-ligand 1 blockade with photothermal ablation for enhanced colorectal cancer immunotherapy. Acta Biomater. 2023 Feb;157:451-466.

中山大学附属第五医院“优秀青年人才支持计划”。